Thermo Fisher Scientific Cyclin D3 Polyclonal Antibody
Cyclin D3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. Human 시료에 반응하며, 보존제가 없는 액상 형태. 세포주기 조절 단백질 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–4 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human CCND3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787735 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CCND3.
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, characterized by periodic changes in protein abundance through the cell cycle. Cyclins regulate CDK kinases and exhibit distinct expression and degradation patterns that coordinate mitotic events. Cyclin D3 forms a complex with CDK4 or CDK6, essential for G1/S transition, and participates in phosphorylation of tumor suppressor protein Rb. CDK4 activity associated with this cyclin is required for progression through G2 phase into mitosis after UV radiation. Multiple transcript variants encoding different isoforms exist.
Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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