Thermo Fisher Scientific PRRX1 Monoclonal Antibody (OTI6A4), TrueMAB
인간 PRRX1 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P) 실험에 최적화됨. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A4 |
| Immunogen | Full length human recombinant protein of human PRRX1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species. It binds DNA via a helix-turn-helix structure, playing a role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 acts as a transcriptional co-activator enhancing the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates transcriptional activities of creatine kinase-M (muscle), contributing to mesodermal muscle type establishment.
PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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