Thermo Fisher Scientific HTRA2 Monoclonal Antibody (6H8)
HTRA2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(6H8). Western blot, ICC/IF, ELISA에 사용 가능. 인간 시료 반응성. PBS(pH 7.4) 용액 형태로 제공되며 방부제 없음. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6H8 |
| Immunogen | HTRA2 (AAH00096, 359 a.a. ~ 458 a.a.) 부분 재조합 단백질, GST 태그 포함 (GST 태그 MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
RRYIGVMMLT LSPSILAELQ LREPSFPDVQ HGVLIHKVIL GSPAHRAGLR PGDVILAIGE QMVQNAEDVY EAVRTQSQLA VQIRRGRETL TLYVTPEVTE
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, a serine protease called Omi/HtrA2 has been identified, which is released from the mitochondria upon induction of apoptosis. Omi/HtrA2 binds to IAP, and like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N-terminus. Deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis, suggesting its role in the mitochondrial apoptotic pathway.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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