Thermo Fisher Scientific HTRA2 Monoclonal Antibody (3G5)
HTRA2 단백질을 인식하는 Thermo Fisher의 mouse monoclonal antibody(3G5)입니다. Western blot, ICC/IF, ELISA에 사용 가능합니다. Human 시료에 반응하며, affinity chromatography로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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- H00027429-M03
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G5 |
| Immunogen | HTRA2 (AAH00096, 359 a.a. ~ 458 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
RRYIGVMMLT LSPSILAELQ LREPSFPDVQ HGVLIHKVIL GSPAHRAGLR PGDVILAIGE QMVQNAEDVY EAVRTQSQLA VQIRRGRETL TLYVTPEVTE
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. A serine protease, Omi/HtrA2, is released from mitochondria upon induction of apoptosis and binds to IAPs. Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. Deregulated expression of Omi in the cytoplasm induces apoptosis, suggesting its role in the mitochondrial apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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