Thermo Fisher Scientific AP2B1 Monoclonal Antibody (2D5)

Thermo Fisher Scientific AP2B1 Monoclonal Antibody (2D5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
SHGIHRKHLP IHHGSTDAGD SPVGTTTATN LEQPQVIPSQ GDLLGDLLNL DLGPPVNVPQ VSSMQMG

Target Information

Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin-coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane.

There are two characterized adaptors, AP1 and AP2.

• AP1 is associated with clathrin-coated vesicles at the trans-Golgi network.
• AP2 is associated with endocytic clathrin-coated vesicles at the plasma membrane and interacts with Shc and EGF receptor.

AP2 is composed of four subunits: two ~100 kDa gene products (alpha and beta adaptin), and ~50 and ~17 kDa subunits. There are two alpha-adaptin genes, alpha A and alpha C, which show tissue-specific expression patterns.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.