Thermo Fisher Scientific AP2B1 Monoclonal Antibody (2D5)
AP2B1 단백질을 인식하는 Mouse 모노클로날 항체로 Western blot, IHC, ELISA에 적합. 인간 시료 반응성, 비결합형 액상 형태. 고순도 친화크로마토그래피 정제, 안정적 PBS 저장용액 제공.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific AP2B1 Monoclonal Antibody (2D5)
Thermo Fisher Scientific AP2B1 Monoclonal Antibody (2D5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D5 |
| Immunogen | AP2B1 (NP_001273.1, 585 a.a. approximately 651 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SHGIHRKHLP IHHGSTDAGD SPVGTTTATN LEQPQVIPSQ GDLLGDLLNL DLGPPVNVPQ VSSMQMG
Target Information
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin-coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane.
There are two characterized adaptors, AP1 and AP2.
- AP1 is associated with clathrin-coated vesicles at the trans-Golgi network.
- AP2 is associated with endocytic clathrin-coated vesicles at the plasma membrane and interacts with Shc and EGF receptor.
AP2 is composed of four subunits: two ~100 kDa gene products (alpha and beta adaptin), and ~50 and ~17 kDa subunits. There are two alpha-adaptin genes, alpha A and alpha C, which show tissue-specific expression patterns.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.