Thermo Fisher Scientific GeneChip Mouse Gene 1.1 ST Array Plate, 1 x 96 array plate

Applied Biosystems™ GeneChip™ Mouse Gene 1.1 ST Array Plate

The Mouse Gene 1.1 ST Array Plate enables high-throughput expression profiling of 96 samples at a time using the same content as the industry-standard GeneChip™ Mouse Gene 1.0 ST Array.

Comprehensive Design

Whole-transcript arrays are designed to measure both messenger RNA (mRNA) and long intergenic non-coding RNA (lincRNA) transcripts. This provides a complete expression profile of mRNA as well as intermediary lincRNA transcripts that influence mRNA expression.

Research has revealed more than 2,000 long non-coding transcripts in the mouse genome with limited protein-coding potential. Differential expression of these lincRNAs is linked to disease development and cancer progression. Recent studies show that lincRNAs are involved in:

• Regulation of mRNA transcription
• Post-transcriptional modification of mRNA
• Recruitment or inhibition of transcription factors
• Activation and transport of transcription factors
• Interaction with accessory proteins
• Guiding protein complexes to genomic locations

Key Benefits

• Comprehensive coverage for discovering novel biological insights

  • 28,000 coding transcripts

  • 7,000 non-coding transcripts (including ~2,000 lincRNAs)

• Detect alternative splicing events and transcript variants with exon-level probe design
• High reproducibility (Intra-lot correlation coefficient = 0.99)

Content Profile

The Mouse Gene 1.1 ST Array Plates were designed based on the growing understanding of the mouse genome, incorporating numerous identified long intergenic lincRNAs. To further support lincRNA research, the Mouse Gene 2.1 ST Array Plates (sold separately) were developed. Additional lincRNA data were supplemented using RefSeq and lncRNA db.

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