ELK Biotechnology DUOX1 rabbit pAb
DUOX1 단백질을 인식하는 토끼 폴리클로날 항체로 WB에 적합. 인간 및 랫트 시료 반응성. 고순도 IgG, 1 mg/ml 농도. NADPH oxidase 계열 단백질 연구 및 갑상선 호르몬 합성 관련 연구에 활용 가능.
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제품명
DUOX1 rabbit pAb
제품 개요
DUOX1 단백질을 인식하는 토끼 유래 폴리클로날 항체로, Western Blot(WB) 분석에 적합합니다. 인간 및 랫트 시료에서 반응성을 보이며, NADPH oxidase 계열 단백질 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DUOX1 rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human DUOX1 (AA range: 1398–1448) |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 53905 |
| Human Swiss-Prot No | Q9NRD9 |
| Species Reactivity | Human; Rat |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein. Localizes to the apical membrane of epithelial cells. |
배경 정보
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
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