ELK Biotechnology DYL1 rabbit pAb
ELK Biotechnology의 DYL1 rabbit pAb는 인간, 마우스, 랫트 시료에서 IHC 및 IF 분석에 사용되는 폴리클로날 항체입니다. 인간 DYL1 펩타이드(AA 1-50)를 면역원으로 제작되었으며, 세포질 및 미토콘드리아 등 다양한 세포소기관에 위치한 DYL1 단백질 검출에 적합합니다. -20°C에서 1년 보관 가능합니다.
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제품명
DYL1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | IHC; IF |
| Recommended Dilutions | IHC-p 1:50–200 |
| Immunogen | Synthesized peptide derived from human DYL1 (AA range: 1–50) |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 8655 |
| Human Swiss-Prot No | P63167 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, nucleus, mitochondrion. Upon induction of apoptosis, translocates together with BCL2L11 to mitochondria. |
Background
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility.
The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.
[provided by RefSeq, Jul 2008]
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