ELK Biotechnology EGF Receptor (phospho-Tyr1068) rabbit pAb
EGF 수용체의 Tyr1068 인산화 부위를 인식하는 토끼 다클론 항체로, WB 분석에 적합합니다. 세포막 및 세포 내 위치 연구에 활용되며, 인간 및 랫트 시료에 반응합니다. 고순도 IgG 형식으로 -20°C에서 1년 보관 가능합니다.
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제품명
EGF Receptor (phospho-Tyr1068) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Epidermal growth factor receptor (EC 2.7.10.1), Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human EGF Receptor (Tyr1068) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 134 kD |
| Gene ID (Human) | 1956 |
| Human Swiss-Prot No. | P00533 |
| Species Reactivity | Human, Rat |
세포 내 위치
Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Golgi apparatus membrane; Single-pass type I membrane protein.
Nucleus membrane; Single-pass type I membrane protein.
Endosome; Endosome membrane.
Nucleus.
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
[Isoform 2]: Secreted.
Background
The protein encoded by this gene is a transmembrane glycoprotein and a member of the protein kinase superfamily. It functions as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, leading to receptor dimerization and tyrosine autophosphorylation, which promotes cell proliferation. Mutations in this gene are associated with lung cancer. [RefSeq, Jun 2016]
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