ELK Biotechnology GIT2 (phospho-Tyr392) rabbit pAb

제품명

GIT2 (phospho-Tyr392) rabbit pAb

제품 개요

이 항체는 인간 GIT2 단백질의 Tyr392 부위 인산화 펩타이드를 면역원으로 제작된 토끼 폴리클로날 항체입니다. GIT 단백질 패밀리는 G 단백질 연결 수용체 키나아제(GRK)와 상호작용하며, 세포골격 역학, 수용체 내재화, 막 수송 조절에 관여합니다. 본 항체는 GIT2의 인산화 상태 연구에 적합합니다.

제품 사양

Background

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences with respect to ARF GAP activity.