ELK Biotechnology GPX4 rabbit pAb
Human GPX4 단백질을 인식하는 rabbit polyclonal antibody로, WB에 적합하며 1:500–2000 희석 권장. 세포 내 산화 손상 보호 연구에 활용 가능. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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ELK Biotechnology GPX4 rabbit pAb
제품 개요
GPX4 rabbit pAb는 인간 GPX4 단백질을 인식하는 rabbit polyclonal antibody로, 산화 스트레스 및 세포막 지질 과산화 관련 연구에 사용됩니다. 본 항체는 고순도 IgG 형태로 제공되며, Western blot(WB) 분석에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | GPX4 rabbit pAb |
| Alternative Names | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (PHGPx), Glutathione peroxidase 4 (GPx-4), GSHPx-4 |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human GPX4 (AA range: 84–134) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kDa |
| GeneID (Human) | 2879 |
| Human Swiss-Prot No | P36969 |
| Cellular Localization | Isoform Mitochondrial: Mitochondrion; Isoform Cytoplasmic: Cytoplasm |
| Species Reactivity | Human, Rat, Mouse |
Background
The protein encoded by the GPX4 gene belongs to the glutathione peroxidase family, which catalyzes the reduction of hydrogen peroxide, organic hydroperoxides, and lipid hydroperoxides, thereby protecting cells against oxidative damage. This isozyme shows high preference for lipid hydroperoxides and plays a key role in preventing membrane lipid peroxidation and cell death. GPX4 is also essential for normal sperm development and functions as both a peroxidase and a structural protein in mature spermatozoa. Mutations in GPX4 are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). The protein is a selenoprotein containing the rare amino acid selenocysteine (Sec) at its active site, encoded by the UGA codon. The SECIS element in the 3' UTR of the mRNA enables recognition of UGA as a Sec codon. Alternatively spliced transcript variants have been identified for this gene. (RefSeq, Oct 2016)
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