ELK Biotechnology HBG1 rabbit pAb
인간, 랫, 마우스 시료에 반응하는 HBG1 rabbit polyclonal antibody. WB 실험에 적합하며 1:500–2000 희석 권장. 인간 HBG1 유래 합성 펩타이드 면역원 사용. 세포질 및 헤모글로빈 복합체 내 위치 확인 가능.
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ELK Biotechnology HBG1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | HBG1 rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human HBG1 (AA range: 34–84) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 3047 |
| Human Swiss-Prot No | P69891 |
| Cellular localization | Cytosol, hemoglobin complex |
| Species Reactivity | Human, Rat, Mouse |
| Storage | -20°C / 1 year |
Background
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen, and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF), which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
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