ELK Biotechnology M-CSF Receptor (phospho-Tyr923) rabbit pAb
M-CSF Receptor (phospho-Tyr923) rabbit pAb는 인간, 생쥐, 랫트 시료에서 사용 가능한 다클론 항체입니다. WB 및 IHC에 적합하며, 세포막 단백질 M-CSF 수용체의 인산화 형태를 검출합니다. 고특이성 IgG 항체로 -20°C에서 1년 보관 가능합니다.
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M-CSF Receptor (phospho-Tyr923) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | M-CSF Receptor (phospho-Tyr923) rabbit pAb |
| Alternative Names | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, EC 2.7.10.1, Proto-oncogene c-Fms, CD antigen CD115) |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized phospho peptide around human M-CSF Receptor (Tyr923) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 107 kDa |
| Gene ID (Human) | 1436 |
| Human Swiss-Prot No. | P07333 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is the receptor for colony stimulating factor 1 (CSF1), a cytokine that controls the production, differentiation, and function of macrophages. This receptor mediates most biological effects of CSF1. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and a member of the CSF1/PDGF receptor family. Mutations in this gene are associated with predisposition to myeloid malignancy. The first intron contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. (RefSeq, Dec 2013)
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