Thermo Fisher Scientific CNTF Recombinant Rabbit Monoclonal Antibody (121)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits, followed by screening individual clones to select the best candidates for production.

Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Rat CNTF.

Target Information

The CNTF protein is a polypeptide hormone primarily active in the nervous system, promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It acts as a potent survival factor for neurons and oligodendrocytes and may help reduce tissue destruction during inflammatory attacks.

Mutations causing aberrant splicing lead to CNTF deficiency, though this phenotype is not directly linked to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequences has been identified but is considered non-coding. Similar read-through transcription has also been observed in mouse.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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