Thermo Fisher Scientific LIMS1 Polyclonal Antibody
LIMS1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P)에서 사용 가능. 인간 및 다양한 종에 반응하며 항원 친화 크로마토그래피로 정제됨. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- PA530240
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–216 of Human LIMS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.88 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547714 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HCT116
- Predicted reactivity: Human (99%), Mouse (99%), Rat (99%), Zebrafish (95%), Xenopus laevis (97%), Pig (98%), Chicken (95%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The LIMS1 gene encodes an adaptor protein containing five LIM domains (double zinc fingers). It is likely involved in integrin signaling through LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques.
LIMS1 may act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, associated with growth factor receptor kinase signaling pathways. Localization to the periphery of spreading cells suggests a role in integrin-mediated cell adhesion or spreading. Multiple transcript variants encoding different isoforms have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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