Thermo Fisher Scientific TGM2 Monoclonal Antibody (OTI2F9), TrueMAB
인간 TGM2 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot 및 IHC(P) 적용 가능. TrueMAB 포맷으로 고순도 친화 크로마토그래피 정제. PBS/BSA/glycerol 완충액에 보관하며 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F9 |
| Immunogen | Full length human recombinant protein of human TGM2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase or TGase 2) has four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains. tTGase is involved in cell death, proliferation, differentiation, and receptor-mediated endocytosis. Elevated tTGase activity in Alzheimer’s disease brain is associated with polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, contributing to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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