Thermo Fisher Scientific Human RET [M918T], GST Tag, His Tag Recombinant Protein

Thermo Fisher Scientific Human RET [M918T], GST Tag, His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots below 20 µL are not recommended.
• Do not store kinase diluted.
• Properly stored at -80°C, product guaranteed for 6 months from date of purchase.

Human RET M918T, C-terminal fragment (amino acids H658–S1114, NCBI/Protein entry NP_066124.1) with M918T mutation.
N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells.

Validated in:

• LanthaScreen™ Kinase Binding Assay

Features:

• Protocols available for optimized performance
• Multiple pack sizes for convenient use

Related Product:
LanthaScreen™ Eu Kinase Binding Assay

Protein Form: Recombinant

Target Information

RET is a receptor tyrosine kinase belonging to the cadherin superfamily. It plays a crucial role in neural crest development and signal transduction for cell growth and differentiation. RET can undergo oncogenic activation through cytogenetic rearrangement.
Mutations in RET are associated with:

• Multiple endocrine neoplasia type IIA and IIB
• Hirschsprung disease
• Medullary thyroid carcinoma

Two transcript variants encoding different isoforms have been identified for the RET gene. Additional variants have been described but their biological validity remains unconfirmed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.