Thermo Fisher Scientific NSFL1C Polyclonal Antibody
NSFL1C 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 인간 및 마우스 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NSFL1C (Accession Q9UNZ2), corresponding to amino acid residues V119–A169 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2849810 |
Product Specific Information
Antibody detects endogenous levels of total NSFL1C.
Target Information
p47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the Golgi apparatus (specifically to Golgi stacks) and contains one SEP domain and one UBX domain.
Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of Golgi stacks during mitosis and for subsequent reassembly of Golgi stacks after mitosis.
p47 is subject to phosphorylation during mitosis, which inhibits p47-Golgi interaction and is therefore required for proper Golgi stack formation and cisternal regrowth.
Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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