Thermo Fisher Scientific RENT1 Polyclonal Antibody
Rabbit에서 유래한 RENT1(UPF1) 단백항체로, Western blot과 Immunoprecipitation에 적합. 비결합(Unconjugated) 액상 형태이며, 4°C에서 보관. NMD 관련 단백질 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1079 and 1129 of Human regulator of nonsense transcripts 1 (UPF1, UniProt ID: Q92900-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Upf1 is an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons. It functions as an ATP-dependent RNA helicase in the cytoplasm and is a component of cytoplasmic P-bodies. Upf1 phosphorylation mediates translational repression during NMD, facilitating mRNA accessibility to the NMD machinery. Other NMD components include Upf2 and Upf3, which localize to perinuclear and nucleocytoplasmic regions, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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