Thermo Fisher Scientific Neuropilin-1 Monoclonal Antibody (49H9)
Neuropilin-1 단백질을 특이적으로 인식하는 Rabbit 모노클로날 항체. Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 1 mg/mL 농도, 액상 형태로 제공되며 -20°C 보관. VEGF 유도 혈관형성 연구 등 신경 및 암 관련 연구에 적합.
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Thermo Fisher Scientific Neuropilin-1 Monoclonal Antibody (49H9)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 49H9 |
| Immunogen | Human Neuropilin 1 (CD304), amino acids 900–C-terminus (UniProt ID: O14786-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
Neuropilin 1 is a 923-amino-acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin 1 forms a heterodimer with Neuropilin 2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors. Predominantly expressed in the nervous system, it plays roles in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis. It acts as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis. Neuropilin 1 may be involved in advanced prostate carcinoma and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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