Thermo Fisher Scientific CTRP3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Product Specifications

Product Specific Information

Immunogen sequence:
MYSYEMKGKS DTSSNHAVLK LAKGDEVWLR MGNGALHGDH QRFSTFAGFL LFET

Sequence identity:

• Mouse: 98%
• Rat: 98%

Target Information

Adipose tissue plays a major role in regulating physiological and pathological processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1–7.

Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. The crystal structure analysis of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Multiple isoforms of human CTRP3 have been reported, and CTRP3 may play a role in skeletal development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.