Thermo Fisher Scientific JSRP1 Polyclonal Antibody
JSRP1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 인간 시료 반응성이 있으며, 액상 형태로 안정적인 장기 보관이 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:5,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human JSRP1. Recombinant protein control fragment (Product #RP-99141). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642861 |
Product Specific Information
Immunogen sequence:
EAEVRPKIPG SREAAENDEE EPGEATGEAV REDRVTLADR GPKERPRREG KPRKEKPRKE ERPKKERPRK EER
Highest antigen sequence identity to the following orthologs:
- Mouse: 42%
- Rat: 48%
Target Information
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR) of the T-tubule serve as voltage sensors in excitation–contraction coupling, while ryanodine receptors (RyR), the calcium release channels, exist in the membrane of the terminal cisternae of the SR.
It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (95 kDa), transmits electrochemical signals to the SR through direct interaction with both DHPR and RyR. Another skeletal muscle–specific 90 kDa protein has also been localized to this junction. This protein is phosphorylated by an intrinsic protein kinase in triads, suggesting that it may play an important regulatory or structural role in the skeletal muscle triad junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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