Thermo Fisher Scientific RNF216 Polyclonal Antibody
Human RNF216 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 용액 형태로 제공. NF-κB 활성화 및 TLR 신호전달 연구에 활용 가능.
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Thermo Fisher Scientific RNF216 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RNF216. Recombinant protein control fragment (Product #RP-92071). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789805 |
Product Specific Information
Immunogen sequence:
VKETEARFPD VANGFIEEII HFKNYYDLNV LCNFLLENPD YPKREDRIII NPSSSLLASQ DETKLPKIDF FDYSKLTPLD
Target Information
Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms exist to control TLR signal transduction, including inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR. Another mechanism involves ubiquitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A binds to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing ubiquitization and promoting degradation of these molecules. Overexpression of TRIAD3A reduces TLR4 and TLR9 activation, while depletion enhances TLR signaling.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-82649_RNF216_Q9NWF9-2_Rabbit.svg, PA5-82649_RNF216_Q9NWF9-2_Rabbit_PDP.jpeg)
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