Thermo Fisher Scientific CD83 Polyclonal Antibody
CD83 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며 Human, Mouse, Rat 반응성을 가집니다. 고순도 Affinity Chromatography 정제, PBS/glycerol 저장, 연구용으로 사용됩니다.
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- PA5114994
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD83 (Accession Q01151), corresponding to amino acid residues Q110–I160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899630 |
Product Specific Information
Antibody detects endogenous levels of total CD83.
Target Information
CD83 cell surface antigen is a 40–45 kDa glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can express low levels of CD83 after stimulation with agents such as Con A or PHA.
In immunohistology, CD83 is strongly expressed by interfollicular interdigitating reticulum cells and weakly by cells within germinal centers. It is also expressed by Langerhans cells in the skin.
The CD83 antigen is a 186-amino-acid single-chain glycoprotein, a member of the immunoglobulin superfamily composed of:
- An extracellular V-type Ig-like domain
- A transmembrane region
- A short 40-amino-acid cytoplasmic tail
CD83 undergoes extensive post-translational glycosylation, doubling its molecular weight compared to the predicted core protein. CD83⁺ cells exhibit a unique immunophenotype distinct from T, B, NK, or myelomonocytic cells, and coexpress high levels of MHC class II molecules. They also express markers such as CD2, CD5, CD40, CD78, CD13, CD33, CD36, and various cytokine receptors.
Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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