Thermo Fisher Scientific CD83 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CD83.

Target Information

CD83 cell surface antigen is a 40–45 kDa glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can express low levels of CD83 after stimulation with agents such as Con A or PHA.
In immunohistology, CD83 is strongly expressed by interfollicular interdigitating reticulum cells and weakly by cells within germinal centers. It is also expressed by Langerhans cells in the skin.

The CD83 antigen is a 186-amino-acid single-chain glycoprotein, a member of the immunoglobulin superfamily composed of:

• An extracellular V-type Ig-like domain
• A transmembrane region
• A short 40-amino-acid cytoplasmic tail

CD83 undergoes extensive post-translational glycosylation, doubling its molecular weight compared to the predicted core protein. CD83⁺ cells exhibit a unique immunophenotype distinct from T, B, NK, or myelomonocytic cells, and coexpress high levels of MHC class II molecules. They also express markers such as CD2, CD5, CD40, CD78, CD13, CD33, CD36, and various cytokine receptors.
Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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