Thermo Fisher Scientific CRMP1 Recombinant Rabbit Monoclonal Antibody (JU73-30)
CRMP1 단백질을 인식하는 재조합 토끼 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. 인간 반응성, 높은 특이성과 재현성 제공. 단백질 A 정제, 액상 형태로 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JU73-30 |
| Immunogen | Synthetic peptide within Human CRMP1 (aa 489–538) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848544 |
Product Specific Information
Positive Control: Mouse brain tissue, N2A, SHG-44, SH-SY5Y, rat brain tissue, mouse cerebellum tissue.
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain, playing major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their expression in regions with high synaptic remodeling, such as the cerebellum, hippocampus, and olfactory system, suggests involvement in adult brain plasticity.
CRMP-1, initially identified as a dihydro-pyrimidinase expressed exclusively in the brain, is associated with NT3-induced neurite formation and outgrowth. Its localization shifts from axonal to somatodendritic as neurons mature, indicating roles in early neuronal differentiation and later processes related to neuron survival or death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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