Thermo Fisher Scientific MHC Class I Monoclonal Antibody (VPM19)
Thermo Fisher Scientific의 VPM19 단클론 항체는 양 MHC Class I을 인식하는 항체로, WB, IHC(F), Flow Cytometry, IP에 사용 가능. 단백질 A로 정제된 액상 형태이며, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로 면역반응 분석에 적합.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent
- Flow Cytometry (Flow): 1:25–1:200
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Sheep |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VPM19 |
| Immunogen | Sheep T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745433 |
Product Specific Information
This antibody recognizes the ovine homologue of the human MHC Class I, a monomorphic determinant expressed on the heavy chain of sheep MHC Class I (OLA Class I).
The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections.
Target Information
Like their mammalian counterparts, avian MHC Class I molecules (B-F antigens) consist of a highly polymorphic alpha-chain noncovalently bound to the invariant beta2-microglobulin subunit.
MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, typically cytotoxic T cells.
The monoclonal antibody F21-2 also reacts with turkey MHC Class I.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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