Thermo Fisher Scientific HTR2C Polyclonal Antibody
Rabbit polyclonal antibody against human HTR2C protein. Validated for WB and ICC/IF. Affinity purified and supplied as liquid form in PBS with BSA and glycerol. Suitable for research use only, not for diagnostic or therapeutic applications.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Protein corresponding to Human HTR2C (aa 236–311) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 30% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2633225 |
Product Specific Information
These polyclonal antibodies are of rabbit origin, developed by immunizing animals with specific proteins or peptides. The polyclonal antibody is affinity purified from rabbit serum and tested for functionality in various research applications.
This antibody is intended for Research Use Only and is non-hazardous and non-infectious in nature.
Predicted to react with Monkey, Horse, Pig, Goat, Cat, and Rabbit.
Target Information
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that binds to several receptor subtypes, including the 5-HT2 family of G-protein-coupled receptors, which activate phospholipase C and D signaling pathways.
The HTR2C gene encodes the 2C subtype of serotonin receptor. Its mRNA undergoes multiple RNA editing events, converting adenosine residues to inosines. These edits alter amino acids within the second intracellular loop of the receptor, generating isoforms with differing abilities to interact with G proteins and activate signaling cascades.
Such modifications modulate serotonergic neurotransmission in the central nervous system. Studies have reported abnormalities in 5-HT2C RNA editing patterns in depressed suicide victims.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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