Thermo Fisher Scientific PNAS4 Polyclonal Antibody
PNAS4 단백질을 인식하는 Thermo Fisher Scientific의 goat polyclonal 항체로, WB 및 IHC(P)에서 검증됨. 인간 시료 반응성, 비결합형 액상 형태, 0.5 mg/mL 농도. DNA 손상 반응 및 종양세포 증식 억제 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-ELGKEYKGNAYH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933254 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
PNAS4 is a highly conserved protein with strong homology across plants and animals. Initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4, PNAS4 is activated during early DNA damage response. It can inhibit proliferation via apoptosis when overexpressed in tumor cells such as U2OS, SKOV3, and A549.
PNAS4 inhibits tumor cell proliferation through:
- S phase arrest by regulating cell cycle-related proteins.
- Induction of apoptosis via the mitochondrial pathway.
Recent studies suggest PNAS4 may be involved in cancer genesis and could serve as a potential candidate for lung cancer therapy, alone or combined with gemcitabine. At least two isoforms of PNAS4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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