Thermo Fisher Scientific TCOF1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TCOF1. Recombinant protein control fragment (Product #RP-96814). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TCOF1,uniProtId:Q13428-1,ncbiNodeId:9606,antigenRange:1045-1129,antigenLength:1488,antigenImageFileName:PA5-58309_TCOF1_Q13428-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58309_TCOF1_Q13428-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648324

Product Specific Information

Immunogen sequence: ESSRISDGKK QEGPATQVSK KNPASLPLTQ AALKVLAQKA SEAQPPVART QPSSGVDSAV GTLPATSPQS TSVQAKGTNK LRKPK

Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 32%.

Target Information

Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.