Thermo Fisher Scientific Phospho-FGFR1 (Tyr766) Polyclonal Antibody
FGFR1 단백질의 Tyr766 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Protein A 정제, 안정적 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific Phospho-FGFR1 (Tyr766) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr766 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family, which includes four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity receptors for 17 growth factors (FGF1–17) and play crucial roles in mesoderm induction, cell growth, migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic development and in adult tissues. Mutations or defects in FGFR1 are associated with various diseases such as Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia/lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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