Thermo Fisher Scientific CD2/Lymphocyte Function Antigen 2 (LFA-2) Monoclonal Antibody (UMCD2)
인간 CD2/LFA-2 항원을 인식하는 UMCD2 클론 단일클론 항체. Western blot, ICC/IF, Flow cytometry, 기능 분석에 적합. Protein A/G 정제, 액상 형태로 제공되며 4°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMCD2 |
| Immunogen | Human Thymocytes / Sezary T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD2 (LFA-2) is a monomeric surface antigen (MW 45–58 kDa) of the human T-lymphocyte lineage, expressed on nearly all peripheral blood T cells and more than 95% of thymocytes. It is also found on some natural killer cells but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating its role as the erythrocyte receptor. Interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen-presenting or target cells.
Although CD2–CD58 binding affinity is relatively low in solution, it is strengthened within the cell-cell interface. T cell activation increases CD2 expression and mobility, enhancing contact and adhesion. CD2 deficiency can reduce intestinal inflammation and aid in infection control.
Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to thymus absence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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