Thermo Fisher Scientific APBA3/Mint3/X11gamma Polyclonal Antibody
APBA3/Mint3/X11gamma 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. 다양한 조직 및 세포 샘플에서 WB, IHC, ICC, ELISA에 사용 가능. 고순도 Protein A 정제, 안정적 액상 형태로 연구용 적합.
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Thermo Fisher Scientific APBA3/Mint3/X11gamma Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from rat Mint3, amino acids 241–340 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The munc-18 interacting protein (Mint) family consists of adaptor proteins involved in membrane transport and organization. Mammals express three isoforms: Mint1, Mint2, and Mint3.
Mint1 and Mint2 are brain-specific and interact with Munc18, a key synaptic vesicle fusion component. Mint3 is ubiquitously expressed, with lower levels in brain and testis, and does not interact with Munc18.
Mint3 binds to the Alzheimer’s disease-related amyloid precursor protein (APP) through PTB and PDZ domains, potentially linking APP to transport machinery and regulating its endocytosis and metabolism.
Abnormal APP metabolism is associated with early-onset Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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