Thermo Fisher Scientific CCM2 Polyclonal Antibody
Human CCM2 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 완충액에 보관. 세포골격 구조 및 세포 간 상호작용 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCM2. Recombinant protein control fragment (Product # RP-92736) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2639514 |
Product Specific Information
Immunogen sequence:
GKKGKKPGIV SPFKRVFLKG EKSRDKKAHE KVTERRPLHT VVLSLPERVE PDRLLSDYIE KEVKYLGQLT SIPGYLNPSS R
- Highest antigen sequence identity to orthologs:
- Mouse: 99%
- Rat: 98%
Target Information
This gene encodes a scaffold protein involved in the stress-activated p38 MAPK signaling cascade. It interacts with SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is essential for maintaining normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene are associated with cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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