Thermo Fisher Scientific SETD1B Polyclonal Antibody
Human SETD1B 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P) 및 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS(glycerol 포함) 용액 형태로 제공되며, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SETD1B. Recombinant protein control fragment (Product #RP-93579). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647165 |
Product Specific Information
Immunogen sequence:
DSLGMEEEVD IETEAVAPEE RPSMLDEPPL PVGVEEPADS REPPEEPGLS QEGAMLLSPE PPAKEVEARP PLSPER
Antigen sequence identity:
- Mouse: 56%
- Rat: 54%
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA. VISA is a mitochondrial membrane protein that acts as a critical component in the IFN-β signaling pathways, recruiting IRF-3 to RIG-I, leading to activation of NF-kappa-B. VISA also interacts with TLR adapter protein TRIF, TRAF2, and TRAF6, as well as IKK-α, IKK-β, and IKK-ι kinases. Cleavage of VISA’s C-terminal region by the Hepatitis C virus (HCV) protease allows viral immune evasion. At least three isoforms of VISA are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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