Thermo Fisher Scientific NOX4 Recombinant Rabbit Monoclonal Antibody (ARC0815)
Rabbit monoclonal antibody recognizing human NOX4 protein. Validated for Western Blot with high specificity and reproducibility. Recombinant antibody expressed in HEK293 cells. Suitable for research on redox signaling and oxygen sensing mechanisms.
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Applications
Tested Application
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0815 |
| Immunogen | A synthetic peptide corresponding to amino acids 479–578 of human NOX4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.37 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849286 |
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.
NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways contributing to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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