Thermo Fisher Scientific Granzyme B (NK/T-Cell Lymphoma Marker) Recombinant Mouse Monoclonal Antibody (rGZMB/4538)
Granzyme B를 인식하는 마우스 유래 재조합 단클론 항체로, NK/T세포 림프종 마커로 활용 가능. Western blot, IHC, Immunoelectrophoresis에 적합. HEK293 세포에서 발현되며, Protein A/G로 정제된 액상 형태. 세포독성 T세포 및 NK세포 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rGZMB/4538 |
| Immunogen | Recombinant fragment of human GZMB protein (around aa 73–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: A431 cells, human tonsil, spleen, or Hodgkin’s lymphoma tissue (IHC).
- Cellular Localization: Cytoplasm
Specificity Comments:
Granzyme B is a granule serine protease stored specifically in NK cells and cytotoxic T cells. Cytolytic T lymphocytes (CTLs) and NK cells recognize and lyse target cells bearing surface antigens from intracellular pathogens. Granzyme B plays a crucial role in inducing apoptosis of target cells during immune responses and serves as a marker for NK/T-cell lymphomas. High cytotoxic T-cell percentages can indicate poor prognosis in Hodgkin’s disease.
Target Information
Granzyme B is a member of the granzyme serine protease family found in cytotoxic T cells and NK cells. It is also known as CGL1 or CTLA-1 and is expressed only in activated cytotoxic T lymphocytes. Granzyme B induces apoptosis in target cells through interaction with the mannose 6-phosphate receptor, initiating caspase-3 activation and DNA fragmentation. It can also activate mitochondrial apoptosis by cleaving Bid protein. Granzymes (A–G in mice) are neutral serine proteases stored in lytic granules of CTLs and NK cells. In humans, fewer granzymes have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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