Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI7B10), TrueMAB
Human TIM-3 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 Flow cytometry에 적합. 고순도의 액상 포맷(1 mg/mL)으로 제공되며, PBS/BSA/glycerol 완충액에 보존. 면역조절 및 자가면역 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B10 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region. It is involved in macrophage activation and induction of autoimmune diseases.
TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates the development of immune tolerance.
Pathological significance of TIM3 has been linked to experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease that enhances disease severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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