Thermo Fisher Scientific NOD1 Polyclonal Antibody
NOD1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합. 인간, 마우스, 랫, 영장류에 반응. 합성 펩타이드 면역원으로 제작되었으며 항원 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of Nod1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 172 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980617 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins involved in innate immune defense.
NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus.
The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B.
LRRs participate in protein-protein interactions, and mutations in the NBD may affect oligomerization and function of the LRR domain.
This protein acts as an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to bacterial diaminopimelic acid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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