Thermo Fisher Scientific Human ABL1 [F317L], GST Tag Recombinant Protein

Thermo Fisher Scientific Human ABL1 [F317L], GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: -

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots below 20 µL are not recommended.
• Do not store kinase diluted.
• Properly stored at -80°C, guaranteed for 6 months from date of purchase.
• Expressed in insect cells (ABL1 F317L recombinant human protein, 27-end).
• Available in multiple pack sizes for convenient use.
• Also available through SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z'-LYTE™ assay.

Protein Form: Recombinant, Active, Mutant
Gene Accession Number: NP_005148.2

Target Information

ABL1 cytoplasmic tyrosine kinase protooncogene encodes a cytoplasmic and nuclear kinase involved in cell differentiation, division, adhesion, and stress response. Activity is negatively regulated by its SH3 domain; deletion of SH3 converts ABL1 into an oncogene. The BCR-ABL1 fusion is found in many cases of chronic myelogenous leukemia. CDK1-mediated phosphorylation regulates the DNA-binding activity of ABL1, suggesting a role in the cell cycle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.