Thermo Fisher Scientific Phospho-Doublecortin (Ser334) Polyclonal Antibody
Phospho-Doublecortin (Ser334) 특이적 폴리클로날 항체로 인간, 생쥐, 랫트 반응성. Western blot, ICC/IF, IP에 적합. 액상 형태로 항원 친화 크로마토그래피로 정제됨. 신경세포 이동 및 미세소관 기능 연구에 활용 가능.
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Thermo Fisher Scientific Phospho-Doublecortin (Ser334) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer334 of doublecortin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987234 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein that directs neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains which bind microtubules. Additionally, DCX interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is essential for proper microtubule function in the developing cortex. Mutations in the DCX gene are associated with X-linked lissencephaly.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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