Thermo Fisher Scientific SCN9A Monoclonal Antibody (1D6)
SCN9A 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(1D6). Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용 가능. Human 반응성, Mouse IgG2b 형식, 고순도 Protein A 정제. 연구용으로만 사용.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D6 |
| Immunogen | Synthetic peptide within Human NaV17 aa 1,577–1,626 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848791 |
Product Specific Information
Positive Control: A549, HeLa, human colon cancer tissue, human kidney tissue.
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share structural similarity, possessing two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
Three homologous isoforms (alpha, beta, gamma) of ENaC play essential roles in sodium and fluid balance in kidney, lung, and colon. ENaC mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
ENaC is regulated partly through interaction with CFTR chloride ion channel. Gain-of-function mutations in beta or gamma ENaC can cause severe arterial hypertension (Liddell’s syndrome), while loss-of-function mutations in alpha or beta ENaC result in pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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