Thermo Fisher Scientific CTHRC1 Monoclonal Antibody (5H1)
CTHRC1 단백질을 인식하는 Mouse Monoclonal Antibody(5H1)로, Western blot 및 IHC(P) 검증됨. 인간 시료 반응성 확인. Protein A 정제, 2.0 mg/mL 농도, -20°C 보관. 연구용으로 혈관 재형성 및 암 전이 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H1 |
| Immunogen | Recombinant protein within Human CTHRC1 (aa 1–243) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS (pH 7.4), with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848792 |
Product Specific Information
Positive Control:
CTHRC1 recombinant protein, rat large intestine tissue, human kidney tissue, human placenta tissue.
Target Information
The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein transiently expressed in the arterial wall in response to injury, contributing to vascular remodeling by inhibiting collagen expression and promoting cell migration.
CTHRC1 is highly expressed in multiple human cancers, including pancreatic cancer, where it plays a significant role in tumor progression and metastasis by regulating migration and adhesion of tumor cells.
Overexpression of CTHRC1 can serve as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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