Thermo Fisher Scientific GADD45B Polyclonal Antibody
GADD45B 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer로 보관하며 -20°C에서 안정합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GADD45B (Accession O75293), corresponding to amino acid residues L117–R160. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850244 |
Product Specific Information
Antibody detects endogenous levels of total GADD45B.
Target Information
Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, allowing time for DNA repair prior to entry into S and M phases. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD45 and p21.
GADD45 binds both Cdks and PCNA, proteins involved in DNA replication and repair. GADD45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
It has been suggested that GADD45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair.
GADD45-like proteins, GADD45 beta and GADD45 gamma, are induced by environmental stresses and are thought to activate p38/JNK pathways via MEKK4 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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