Thermo Fisher Scientific CFHR5 Monoclonal Antibody (3E1E10)
Human CFHR5 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA에 사용 가능. 고순도 Protein G 정제, 1 mg/mL 농도, PBS buffer에 0.05% sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E1E10 |
| Immunogen | Purified recombinant fragment of human CFHR5 (AA: 344–569) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787301 |
Product Specific Information
MA5-31677 has been tested in indirect ELISA.
Target Information
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation.
The protein encoded by this gene has nine SCRs:
- The first two repeats have heparin binding properties.
- Repeats 5–7 have heparin and C-reactive protein binding properties.
- The C-terminal repeats are similar to a complement component 3b (C3b) binding domain.
This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein.
Allelic variations in this gene have been associated with two kidney diseases: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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