Thermo Fisher Scientific Human Epiregulin, Animal-Free Recombinant Protein, PeproTech
인체 유래 Epiregulin 재조합 단백질로, 동물성 성분이 없는 E. coli 발현 시스템에서 생산됩니다. 세포 증식 활성 검증 완료, 고순도(≥98%) 및 저엔도톡신(<0.1 EU/µg) 수준을 보장합니다. 연구용으로 적합하며 EGFR 및 ErbB4 결합 특성을 지닙니다.
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Applications
- Functional Assay (Functional): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL |
| Molecular Weight | 5.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Stimulates proliferation of mouse Balb/3T3 cells; ED50 ≤ 0.2 ng/ml; Specific activity ≥ 5 × 10^6 units/mg |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human Epiregulin is a 5.6 kDa monomeric protein containing 50 amino acid residues, corresponding to the mature secreted Epiregulin sequence.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not to ErbB2 or ErbB3. It is mainly expressed in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney, and colon.
Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts, and vascular smooth muscle cells, while inhibiting the growth of several tumor-derived epithelial cell lines.
Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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