Thermo Fisher Scientific ERCC5/XPG Polyclonal Antibody
Thermo Fisher Scientific의 ERCC5/XPG Polyclonal Antibody는 인간 XPG 단백질을 표적으로 하는 Rabbit IgG 항체로, WB, IHC, IP에 사용 가능합니다. DNA 손상 복구 연구에 적합하며, 액상 형태로 4°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:20–1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 and 700 of human excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight.
The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is essential for DNA repair of solar UV-induced DNA damages.
Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA, cleaving model DNA bubble structures near the junction of unpaired DNA with a duplex region.
A 29-amino acid region of human XPG (residues 981–1009) contains the PCNA binding activity, with Arg992 crucial for PCNA binding.
Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, XPA and XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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