Thermo Fisher Scientific ERCC5/XPG Polyclonal Antibody
Thermo Fisher Scientific의 ERCC5/XPG Polyclonal Antibody는 인간 XPG 단백질을 인식하는 토끼 IgG 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, DNA 손상 복구 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1136 and 1186 of human excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G, Cockayne syndrome). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight.
The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is essential for repairing UV-induced DNA damage.
Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA, cleaving DNA bubble structures near the junction of unpaired and duplex regions.
A 29-amino acid region (residues 981–1009) contains PCNA binding activity, with Arg992 crucial for this interaction.
Replication Protein A (RPA) binds specifically and directly to two excision repair proteins: XPA and XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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