Thermo Fisher Scientific SCIMP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SCIMP. Recombinant protein control fragment (Product #RP-88833). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SCIMP,uniProtId:Q6UWF3-1,ncbiNodeId:9606,antigenRange:47-141,antigenLength:145,antigenImageFileName:PA5-52254_SCIMP_Q6UWF3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52254_SCIMP_Q6UWF3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647004

Product Specific Information

Immunogen sequence: RRGKKWEIAK PLKHKQVDEE KMYENVLNES PVQLPPLPPR NWPSLEDSSP QEAPSQPPAT YSLVNKVKNK KTVSIPSYIE PEDDYDDVEI PANTE

Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 58%.

Target Information

SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.