Thermo Fisher Scientific Human RNAse H2A Synthetic Peptide
Human RNAse H2A 중심부 17개 아미노산 서열 기반 합성 펩타이드. 항체 PA5-20667의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며 PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the center of human RNAse H2A.
PEP-0787 can be used as a blocking peptide with polyclonal antibody PA5-20667.
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their primary role is to remove the RNA strand from RNA/DNA hybrids formed during DNA replication and repair.
RNAse H2 consists of three subunits, all necessary for enzymatic activity. Mutations in RNAse H2A or other subunits have been linked to Aicardi-Goutieres syndrome (AGS), a neurological disorder with symptoms similar to viral brain infections, including elevated IFN-alpha levels in cerebrospinal fluid.
Similar pathologies are seen with TREX1 mutations, suggesting that RNAse H2 and TREX1 have related functions. Mutations in these genes may cause intracellular nucleic acid accumulation, triggering an inflammatory response via innate immune activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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