Thermo Fisher Scientific Human TREX2 Synthetic Peptide
휴먼 TREX2 단백질의 C-말단 15 아미노산 서열을 기반으로 한 합성 펩타이드입니다. PA5-20666 항체의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태이며 PBS 버퍼에 0.1% BSA, 0.02% sodium azide를 포함합니다. 연구용으로만 사용됩니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human TREX2.
PEP-0786 can be used as a blocking peptide with polyclonal antibody PA5-20666.
Target Information
TREX2 is one of two major human 3′ to 5′ exonucleases required for checkpoint signaling after DNA damage.
While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2.
Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2–single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double-stranded DNA and feeds the substrate DNA strand into the TREX2 active site.
At least two isoforms of TREX2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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